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期刊名称: Pathology & Oncology Research
Volume:24    Issue:3        Page:583-592
ISSN:1219-4956

High- and low-Molecular Weight oat Beta-Glucan Reveals Antitumor Activity in Human Epithelial Lung Cancer期刊论文

作者: Choromanska Anna Kulbacka Julita Harasym Joanna Oledzki Remigiusz Szewczyk Anna
DOI:10.1007/s12253-017-0278-3

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页码: 583-592
被引频次: 11
出版者: Springer Netherlands,SPRINGER,Springer
期刊名称: Pathology & Oncology Research
ISSN: 1219-4956
卷期: Volume:24    Issue:3
语言: English
摘要: Beta-glucans are widely used in treatment, cosmetics, and the food industry. Glucans play a significant role in activation of the immune and antioxidant system and inhibiting tumor proliferation. In the current study the antitumor activities of new high and low molecular weight beta-glucan derived from oats were investigated in two human lung cancer cell line (A549, H69AR) and normal keratinocytes (HaCaT). The effect of high and low molecular weight beta-glucan from oat was evaluated by cellular viability assessment, lipid peroxidation and manganese superoxide dismutase evaluation and cytoskeleton visualisation. Additionally the level of red blood cells hemolysis was performed. Our results indicate strong anti-tumor properties of new beta-glucan from oat and at the same time no toxicity for normal cells.
相关主题: Biomedicine, general, Pathology, Oxidative stress, Biomedicine, Immunology, Lung cancer, Keratinocytes, Cancer Research, Oncology, Cytoskeleton, Viability, Oat beta-glucan, CELLS, APOPTOSIS, PATHOLOGY, PORIA-COCOS, ONCOLOGY, IMMUNOTHERAPY, ANTIOXIDANT, FUNGAL, MICE, BLOOD, Antioxidants, Medical colleges, Superoxide, Original,

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