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期刊名称: Applications of Mathematics
Volume:64    Issue:2        Page:253-277
ISSN:0862-7940

On parameter estimation in an in vitro compartmental model for drug-induced enzyme production in pharmacotherapy期刊论文

作者: Duintjer Tebbens Jurjen Matonoha Ctirad Matthios Andreas Papáček Štěpán
DOI:10.21136/AM.2019.0284-18

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页码: 253-277
被引频次: 0
出版者: Springer Berlin Heidelberg,ACAD SCIENCES CZECH REPUBLIC, INST MATHEMATICS,Springer
期刊名称: Applications of Mathematics
ISSN: 0862-7940
卷期: Volume:64    Issue:2
语言: English
摘要: A pharmacodynamic model introduced earlier in the literature for in silico prediction of rifampicin-induced CYP3A4 enzyme production is described and some aspects of the involved curve-fitting based parameter estimation are discussed. Validation with our own laboratory data shows that the quality of the fit is particularly sensitive with respect to an unknown parameter representing the concentration of the nuclear receptor PXR (pregnane X receptor). A detailed analysis of the influence of that parameter on the solution of the model’s system of ordinary differential equations is given and it is pointed out that some ingredients of the analysis might be useful for more general pharmacodynamic models. Numerical experiments are presented to illustrate the performance of related parameter estimation procedures based on least-squares minimization.
相关主题: Theoretical, Mathematical and Computational Physics, 34A34, Mathematics, Optimization, 92C45, 65F60, Classical and Continuum Physics, Analysis, pharmacotherapy, Mathematical and Computational Engineering, parameter estimation, 65K10, Applications of Mathematics, pharmacodynamic modelling, constrained optimization, MATHEMATICS, APPLIED, Parameter estimation, Usage, Drug therapy, Methods,

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