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期刊名称: Biology of Reproduction
Volume:84    Issue:2        Page:266-278
ISSN:0006-3363

Changes in the endometrial transcriptome during the bovine estrous cycle: Effect of low circulating progesterone and consequences for conceptus elongation期刊论文

作者: Forde Niamh Beltman M.E Duffy G.B Duffy P Mehta J.P
DOI:10.1095/biolreprod.110.085910

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页码: 266-278
被引频次: 164
出版者: OXFORD UNIV PRESS INC
期刊名称: Biology of Reproduction
ISSN: 0006-3363
卷期: Volume:84    Issue:2
语言: English
摘要: In cattle, elevated concentrations of circulating progesterone (P4) in the immediate postconception period are associated with advanced conceptus development, while low P4 is implicated as a causative factor in low pregnancy rates observed in dairy cows. This study aimed to: 1) describe the transcriptional changes that occur in the bovine endometrium during the estrous cycle, 2) determine how elevated P4 affects these changes, 3) identify if low P4 alters the expression of these genes, and 4) assess the impact that low P4 has on conceptus development. Relatively few differences occurred in endometrial gene expression during the early luteal phase of the estrous cycle (Day 5 vs. 7), but comparison of endometria from more distant stages of the luteal phase (Day 7 vs. 13) revealed large transcriptional changes, which were significantly altered by exogenous supplementation of P4. Induction of low circulating P4 altered the normal temporal changes in gene expression, and these changes were coordinate with a delay in the down-regulation of the PGR from the LE and GE. Altered endometrial gene expression induced by low P4 was associated with a reduced capacity of the uterus to support conceptus development after embryo transfer on Day 7. In conclusion, the present study provides clear evidence that the temporal changes in the transcriptome of the endometrium of cyclic heifers are sensitive to circulating P4 concentrations in the first few days after estrus. Under low P4 conditions, a suboptimal uterine environment with reduced ability to support conceptus elongation is observed.
相关主题: Embryo, Progesterone, Gene expression, Progesterone receptor, Endometrium, LOCALIZATION, MESSENGER-RNA EXPRESSION, progesterone, endometrium, embryo, RETINOL-BINDING-PROTEIN, EARLY EMBRYO DEVELOPMENT, EARLY LUTEAL-PHASE, BEEF HEIFERS, progesterone receptor, PREGNANCY, DAIRY-COWS, REPRODUCTIVE BIOLOGY, TISSUE GROWTH-FACTOR, gene expression, MICROARRAY DATA, Gene Expression - drug effects, Embryo, Mammalian, Down-Regulation, Gene Expression Profiling, Progesterone - blood, Embryonic Development, Receptors, Progesterone - metabolism, Pregnancy, Animals, Osmolar Concentration, Estrous Cycle - genetics, Time Factors, Cattle, Embryo Transfer, Female, Dinoprost - pharmacology, Principal Component Analysis, Estrous Cycle - metabolism, Endometrium - metabolism, Index Medicus,

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