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期刊名称: Biology of Reproduction
Volume:91    Issue:3        Page:74-74
ISSN:0006-3363

FSH receptor (FSHR) expression in human extragonadal reproductive tissues and the developing placenta, and the impact of its deletion on pregnancy in mice期刊论文

作者: Stilley Julie A.W Christensen Debora E Dahlem Kristin B Guan Rongbin Santillan Donna A
DOI:10.1095/biolreprod.114.118562

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页码: 74-74
被引频次: 52
出版者: OXFORD UNIV PRESS INC
期刊名称: Biology of Reproduction
ISSN: 0006-3363
卷期: Volume:91    Issue:3
语言: English
摘要: Expression and function of the follicle-stimulating hormone receptor (FSHR) in females were long thought to be limited to the ovary. Here, however, we identify extragonadal FSHR in both the human female reproductive tract and the placenta, and test its physiological relevance in mice. We show that in nonpregnant women FSHR is present on: endothelial cells of blood vessels in the endometrium, myometrium, and cervix; endometrial glands of the proliferative and secretory endometrium; cervical glands and the cervical stroma; and (at low levels) stromal cells and muscle fibers of the myometrium. In pregnant women, placental FSHR was detected as early as 8-10 wk of gestation and continued through term. It was expressed on: endothelial cells in fetal portions of the placenta and the umbilical cord; epithelial cells of the amnion; decidualized cells surrounding the maternal arteries in the maternal decidua; and the stromal cells and muscle fibers of the myometrium, with particularly strong expression at term. These findings suggest that FSHR expression is upregulated during decidualization and upregulated in myometrium as a function of pregnancy. The presence of FSHR in the placental vasculature suggests a role in placental angiogenesis. Analysis of genetically modified mice in which Fshr is lacking in fetal portions of the placenta revealed adverse effects on fetoplacental development. Our data further demonstrate FSHB and CGA mRNAs in placenta and uterus, consistent with potential local sources of FSH. Collectively, our data suggest heretofore unappreciated roles of extragonadal FSHR in female reproductive physiology.
相关主题: Pregnancy, Follicle-stimulating hormone, Placenta, Uterus, Gonadotropin, Cervix, FSH receptor, cervix, follicle-stimulating hormone, ANGIOGENESIS, VASCULOGENESIS, pregnancy, MOUSE, IDENTIFICATION, MICROARRAY ANALYSIS, REPRODUCTIVE BIOLOGY, uterus, STIMULATING-HORMONE RECEPTOR, GONADOTROPINS, GENE-EXPRESSION, OXYTOCIN, placenta, INTRAUTERINE GROWTH RESTRICTION, gonadotropin, Endothelium, Vascular - cytology, Immunohistochemistry, Cervix Uteri - blood supply, Up-Regulation, Cervix Uteri - metabolism, Receptors, FSH - genetics, Humans, Umbilical Cord - cytology, RNA, Messenger - metabolism, Umbilical Cord - metabolism, Gene Expression Regulation, Developmental, Placenta - cytology, Myometrium - metabolism, Adult, Female, Endometrium - cytology, Endometrium - metabolism, Receptors, FSH - metabolism, Myometrium - blood supply, Placentation, Stromal Cells - metabolism, Extraembryonic Membranes - cytology, Mice, Knockout, Myometrium - cytology, Placenta - metabolism, Placenta - blood supply, Animals, Endothelium, Vascular - metabolism, Extraembryonic Membranes - blood supply, Extraembryonic Membranes - metabolism, Cervix Uteri - cytology, Stromal Cells - cytology, Endometrium - blood supply, Index Medicus,

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