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作者 : Liu H ;   Yang H ;   Hao X ;   Xu HJ ;   Lv Y ;   Xiao DB ;   Wang HD ;   Tian ZY ;  
出版者 : SMALL
ISN : 1613-6810
出版年 : 2013
卷 : 9
期 : 15
起始页码 : 2639
终止页码 : 2648
语种 : en
摘要 : A class of core-shell nanoparticles possessing a layer of biocompatible shell and hydrophobic core with embedded oxygen-sensitive platinum-porphyrin (PtTFPP) dyes is developed via a radical-initiated microemulsion co-polymerization strategy. The influences of host matrices and the PtTFPP incorporation manner on the photophysical properties and the oxygen-sensing performance of the nanoparticles are investigated. Self-loading capability with cells and intracellular-oxygen-sensing ability of the as-prepared nanoparticle probes in the range 0%-20% oxygen concentration are confirmed. Polymeric nanoparticles with optimized formats are characterized by their relatively small diameter (<50 nm), core-shell structures with biocompatible shells, covalent-attachment-imparted leak-free construction, improved lifetime dynamic range (up to 44 s), excellent storage stability and photostability, and facile cell uptake. The nanoparticles' small sensor diameter and core-shell structure with biocompatible shell make them suitable for intracellular detection applications. For intracellular detection applications, the leak-free feature of the as-prepared nanoparticle sensor effectively minimizes potential chemical interferences and cytotoxicity. As a salient feature, improved lifetime dynamic range of the sensor is expected to enable precise oxygen detection and control in specific practical applications in stem-cell biology and medical research. Such a feature-packed nanoparticle oxygen sensor may find applications in precise oxygen-level mapping of living cells and tissue.


Design of Self-Assembling Peptide Nanotubes with Delocalized Electronic States[**]期刊论文

作者:Nurit Ashkenasy,W. Seth Horne,M. Reza Ghadiri等   ISSN:1613-6810;1613-6829;  publication-date:2007-1-8  Volume:2  Issue:1  Page:99-102  

One-pot synthesis of CdTe nanocrystals and shape control of luminescent CdTe-cystine nanocomposites期刊论文

作者:Bao HF,Wang EK,Dong SJ等   ISSN:1613-6810  publication-date:2006  Volume:2  Issue:4  Page:476-480  

Site-specific ligation of DNA-modified gold nanoparticles activated by the restriction enzyme StyI期刊论文

作者:Kanaras AG,Wang ZX,Hussain I,Brust M,Cosstick R,Bates AD等   ISSN:1613-6810  publication-date:2007  Volume:3  Issue:1  Page:67-70  

Nanoscale phase-aggregation-induced performance improvement of polymer solar cells期刊论文

作者:Yang XN,Lu GH,Li LG,Zhou EL等   ISSN:1613-6810  publication-date:2007  Volume:3  Issue:4  Page:611-615  

Creating a uniform distribution of fullerene C-60 nanorods in a polymer matrix and its photovoltaic applications期刊论文

作者:Lu GH,Li LG,Yang XN等   ISSN:1613-6810  publication-date:2008  Volume:4  Issue:5  Page:601-606  

Self-assembly of single-stranded RNA on carbon nanotube: Polyadenylic acid to form a duplex structure期刊论文

作者:Zhao C,Peng YH,Song YJ,Ren JS,Qu XG等   ISSN:1613-6810  publication-date:2008  Volume:4  Issue:5  Page:656-661  

Label-Free Colorimetric Detection of Small Molecules Utilizing DNA Oligonucleotides and Silver Nanoparticles期刊论文

作者:Xu XW,Wang J,Yang F,Jiao K,Yang XR等   ISSN:1613-6810  publication-date:2009  Volume:5  Issue:23  Page:2669-2672  

Polyaniline/Pt Hybrid Nanofibers: High-Efficiency Nanoelectrocatalysts for Electrochemical Devices期刊论文

作者:Guo SJ,Dong SJ,Wang EK等   ISSN:1613-6810  publication-date:2009  Volume:5  Issue:16  Page:1869-1876  

A renewable SERS substrate prepared by cyclic depositing and stripping of silver shells on gold nanoparticle microtubes期刊论文

作者:Wang T,Hu XG,Dong SJ等   ISSN:1613-6810  publication-date:2008  Volume:4  Issue:6  Page:781-786  

Shape- and size-controlled synthesis and dependent magnetic properties of nearly monodisperse Mn3O4 nanocrystals期刊论文

作者:Zhao NN,Nie W,Liu XB,Tian SZ,Zhang Y,Ji XL等   ISSN:1613-6810  publication-date:2008  Volume:4  Issue:1  Page:77-81  





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