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作者 : Liu H ;   Yang H ;   Hao X ;   Xu HJ ;   Lv Y ;   Xiao DB ;   Wang HD ;   Tian ZY ;  
关键词 : OPTICAL CHEMICAL SENSORS;BRAIN-TUMOR DELINEATION;MOLECULAR-OXYGEN;DISSOLVED-OXYGEN;PEBBLE SENSORS;LIVE CELLS;SOL-GEL;LIVING CELLS;IN-VIVO;NANOSENSORS;
出版者 : SMALL
ISN : 1613-6810
出版年 : 2013
卷 : 9
期 : 15
起始页码 : 2639
终止页码 : 2648
语种 : en
摘要 : A class of core-shell nanoparticles possessing a layer of biocompatible shell and hydrophobic core with embedded oxygen-sensitive platinum-porphyrin (PtTFPP) dyes is developed via a radical-initiated microemulsion co-polymerization strategy. The influences of host matrices and the PtTFPP incorporation manner on the photophysical properties and the oxygen-sensing performance of the nanoparticles are investigated. Self-loading capability with cells and intracellular-oxygen-sensing ability of the as-prepared nanoparticle probes in the range 0%-20% oxygen concentration are confirmed. Polymeric nanoparticles with optimized formats are characterized by their relatively small diameter (<50 nm), core-shell structures with biocompatible shells, covalent-attachment-imparted leak-free construction, improved lifetime dynamic range (up to 44 s), excellent storage stability and photostability, and facile cell uptake. The nanoparticles' small sensor diameter and core-shell structure with biocompatible shell make them suitable for intracellular detection applications. For intracellular detection applications, the leak-free feature of the as-prepared nanoparticle sensor effectively minimizes potential chemical interferences and cytotoxicity. As a salient feature, improved lifetime dynamic range of the sensor is expected to enable precise oxygen detection and control in specific practical applications in stem-cell biology and medical research. Such a feature-packed nanoparticle oxygen sensor may find applications in precise oxygen-level mapping of living cells and tissue.

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