National Science Library, Chinese Academy of Sciences
  登录 机构网站 ENGLISH
您当前的位置是: 首页-> 详细浏览
服务链接:
作者 : Chen CE ;   Zhou L ;   Geng J ;   Ren JS ;   Qu XG ;  
关键词 : MESOPOROUS SILICA NANOPARTICLES;CONTROLLED-RELEASE;GUEST MOLECULES;TELOMERASE INHIBITION;CATIONIC PORPHYRINS;CLICK CHEMISTRY;PH;NANOVALVES;BINDING;FUNCTIONALIZATION;
出版者 : SMALL
ISN : 1613-6810
出版年 : 2013
卷 : 9
期 : 16
起始页码 : 2793
终止页码 : 2800
语种 : en
摘要 : A novel light-operated vehicle for targeted intracellular drug delivery is constructed using photosensitizer-incorporated G-quadruplex DNA-capped mesoporous silica nanoparticles. Upon light irradiation, the photosensitizer generates ROS, causing the DNA capping to be cleaved and allowing cargo to be released. Importantly, this platform makes it possible to develop a drug-carrier system for the synergistic combination of chemotherapy and PDT for cancer treatment with spatial/temporal control. Furthermore, the introducing of targeting ligands further improves tumor targeting efficiency. The excellent biocompatibility, cell-specific intracellular drug delivery, and cellular uptake properties set up the basis for future biomedical application that require in vivo controlled, targeted drug delivery.

相关文献推荐:

Multifunctional Upconversion Mesoporous Silica Nanostructures for Dual Modal Imaging and In Vivo Drug Delivery期刊论文

作者:Li CX,Yang DM,Ma PA,Chen YY,Wu Y,Hou ZY,Dai YL,Zhao JH,Sui CP,Lin J等   ISSN:1613-6810  publication-date:2013  Volume:9  Issue:24  Page:4150-4159  

Aptamer-Directed Synthesis of Multifunctional Lanthanide-Doped Porous Nanoprobes for Targeted Imaging and Drug Delivery期刊论文

作者:Zhou L,Li ZH,Ju EG,Liu Z,Ren JS,Qu XG等   ISSN:1613-6810  publication-date:2013  Volume:9  Issue:24  Page:4262-4268  

Self-Assembled Peptide-Polyoxometalate Hybrid Nanospheres: Two in One Enhances Targeted Inhibition of Amyloid beta-Peptide Aggregation Associated with Alzheimer's Disease期刊论文

作者:Li M,Xu C,Wu L,Ren JS,Wang EB,Qu XG等   ISSN:1613-6810  publication-date:2013  Volume:9  Issue:20  Page:3455-3461  

Photosensitizer-Incorporated Quadruplex DNA-Gated Nanovechicles for Light-Triggered, Targeted Dual Drug Delivery to Cancer Cells期刊论文

作者:Chen CE,Zhou L,Geng J,Ren JS,Qu XG等   ISSN:1613-6810  publication-date:2013  Volume:9  Issue:16  Page:2793-2800  

Development of Polymeric Nanoprobes with Improved Lifetime Dynamic Range and Stability for Intracellular Oxygen Sensing期刊论文

作者:Liu H,Yang H,Hao X,Xu HJ,Lv Y,Xiao DB,Wang HD,Tian ZY等   ISSN:1613-6810  publication-date:2013  Volume:9  Issue:15  Page:2639-2648  

Nanoparticles for Gene Delivery期刊论文

作者:Tian HY,Chen J,Chen XS等   ISSN:1613-6810  publication-date:2013  Volume:9  Issue:12  Page:2034-2044  

Electrochemical Synthesis of Transparent, Amorphous, C60-Rich, Photoactive, and Low-Doped Film with an Interconnected Structure期刊论文

作者:Li M,Ishihara S,Ohkubo K,Liao MY,Ji QM,Gu C,Pan YY,Jiang XF,Akada M,Hill JP,Nakanishi T,Ma YG,Yamauchi Y,Fukuzumi S,Ariga K等   ISSN:1613-6810  publication-date:2013  Volume:9  Issue:12  Page:2064-2068  

Large-Area 2D Gold Nanorod Arrays Assembled on Block Copolymer Templates期刊论文

作者:Liu ZC,Huang HY,He TB等   ISSN:1613-6810  publication-date:2013  Volume:9  Issue:4  Page:505-510  

In Situ Monitoring Alzheimer's Disease ss-Amyloid Aggregation and Screening of A ss Inhibitors Using a Perylene Probe期刊论文

作者:Li M,Zhao CQ,Yang XJ,Ren JS,Xu C,Qu XG等   ISSN:1613-6810  publication-date:2013  Volume:9  Issue:1  Page:52-55  

Transmission Electron Microscopy and the Science of Carbon Nanomaterials期刊论文

作者:B S Zhang,D S Su等   ISSN:1613-6810  publication-date:2014  Volume:10  Issue:2  Page:222-229  

问图书管理员更多图书管理员

学科咨询馆员
学科馆员

电话:
邮件:
问图书馆员

图标说明

在线获取原文 原文传递 详细信息 图书在架状态 图书馆际互借 问图书馆员

常见问题

图书馆开放时间 图书馆位置 借阅要求 您在使用中发现的任何错误,都可以向我们 【报告错误】,非常感谢!

作者信息:×