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作者 : Chen CE ;   Zhou L ;   Geng J ;   Ren JS ;   Qu XG ;  
关键词 : MESOPOROUS SILICA NANOPARTICLES;CONTROLLED-RELEASE;GUEST MOLECULES;TELOMERASE INHIBITION;CATIONIC PORPHYRINS;CLICK CHEMISTRY;PH;NANOVALVES;BINDING;FUNCTIONALIZATION;
出版者 : SMALL
ISN : 1613-6810
出版年 : 2013
卷 : 9
期 : 16
起始页码 : 2793
终止页码 : 2800
语种 : en
摘要 : A novel light-operated vehicle for targeted intracellular drug delivery is constructed using photosensitizer-incorporated G-quadruplex DNA-capped mesoporous silica nanoparticles. Upon light irradiation, the photosensitizer generates ROS, causing the DNA capping to be cleaved and allowing cargo to be released. Importantly, this platform makes it possible to develop a drug-carrier system for the synergistic combination of chemotherapy and PDT for cancer treatment with spatial/temporal control. Furthermore, the introducing of targeting ligands further improves tumor targeting efficiency. The excellent biocompatibility, cell-specific intracellular drug delivery, and cellular uptake properties set up the basis for future biomedical application that require in vivo controlled, targeted drug delivery.

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