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作者 : Li CX ;   Yang DM ;   Ma PA ;   Chen YY ;   Wu Y ;   Hou ZY ;   Dai YL ;   Zhao JH ;   Sui CP ;   Lin J ;  
关键词 : NANOCRYSTAL CORE/SHELL STRUCTURE;RAY COMPUTED-TOMOGRAPHY;MAGNETIC-RESONANCE;PHOTOTHERMAL THERAPY;SURFACE MODIFICATION;SYSTEMIC TOXICITY;POROUS NAYF4/YB3+;CONTRAST AGENT;CANCER-THERAPY;NANOPARTICLES;
出版者 : SMALL
ISN : 1613-6810
出版年 : 2013
卷 : 9
期 : 24
起始页码 : 4150
终止页码 : 4159
语种 : en
摘要 : Incorporating the agents for magnetic resonance imaging (MRI), optical imaging, and therapy in one nanostructured matrix to construct multifunctional nanomedical platform has attracted great attention for simultaneous diagnostic and therapeutic applications. In this work, a facile methodology is developed to construct a multifunctional anticancer drug nanocarrier by combining the special advantages of upconversion nanoparticles and mesoporous silica. -NaYF4:Yb3+, Er3+@-NaGdF4:Yb3+ is chosen as it can provide the dual modality of upconversion luminescence and MRI. Then mesoporous silica is directly coated onto the upconversion nanoparticles to form discrete, monodisperse, highly uniform, and core-shell structured nanospheres (labeled as UCNPs@mSiO(2)), which are subsequently functionalized with hydrophilic polymer poly(ethylene glycol) (PEG) to improve the colloidal stability and biocompatibility. The obtained multifunctional nanocomposites can be used as an anticancer drug delivery carrier and applied for imaging. The anticancer drug doxorubicin (DOX) is absorbed into UCNPs@mSiO(2)-PEG nanospheres and released in a pH-sensitive pattern. In vitro cell cytotoxicity tests on cancer cells verify that the DOX-loaded UCNPs@mSiO(2)-PEG has comparable cytotoxicity with free DOX at the same concentration of DOX. In addition, the T-1-weighted MRI that measures in aqueous solutions reveals that the contrast brightening increases with the concentration of Gd3+ component. Upconversion luminescence images of UCNPs@mSiO(2)-PEG uptaken by cells show green emission under 980 nm infrared laser excitation. Finally, the nanocomposites show low systematic toxicity and high in vivo antitumor therapy efficacy. These findings highlight the fascinating features of upconversion-mesoporous nanocomposites as multimodality imaging contrast agents and nanocarrier for drug molecules.

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