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作者 : Li CX ;   Yang DM ;   Ma PA ;   Chen YY ;   Wu Y ;   Hou ZY ;   Dai YL ;   Zhao JH ;   Sui CP ;   Lin J ;  
出版者 : SMALL
ISN : 1613-6810
出版年 : 2013
卷 : 9
期 : 24
起始页码 : 4150
终止页码 : 4159
语种 : en
摘要 : Incorporating the agents for magnetic resonance imaging (MRI), optical imaging, and therapy in one nanostructured matrix to construct multifunctional nanomedical platform has attracted great attention for simultaneous diagnostic and therapeutic applications. In this work, a facile methodology is developed to construct a multifunctional anticancer drug nanocarrier by combining the special advantages of upconversion nanoparticles and mesoporous silica. -NaYF4:Yb3+, Er3+@-NaGdF4:Yb3+ is chosen as it can provide the dual modality of upconversion luminescence and MRI. Then mesoporous silica is directly coated onto the upconversion nanoparticles to form discrete, monodisperse, highly uniform, and core-shell structured nanospheres (labeled as UCNPs@mSiO(2)), which are subsequently functionalized with hydrophilic polymer poly(ethylene glycol) (PEG) to improve the colloidal stability and biocompatibility. The obtained multifunctional nanocomposites can be used as an anticancer drug delivery carrier and applied for imaging. The anticancer drug doxorubicin (DOX) is absorbed into UCNPs@mSiO(2)-PEG nanospheres and released in a pH-sensitive pattern. In vitro cell cytotoxicity tests on cancer cells verify that the DOX-loaded UCNPs@mSiO(2)-PEG has comparable cytotoxicity with free DOX at the same concentration of DOX. In addition, the T-1-weighted MRI that measures in aqueous solutions reveals that the contrast brightening increases with the concentration of Gd3+ component. Upconversion luminescence images of UCNPs@mSiO(2)-PEG uptaken by cells show green emission under 980 nm infrared laser excitation. Finally, the nanocomposites show low systematic toxicity and high in vivo antitumor therapy efficacy. These findings highlight the fascinating features of upconversion-mesoporous nanocomposites as multimodality imaging contrast agents and nanocarrier for drug molecules.


Design of Self-Assembling Peptide Nanotubes with Delocalized Electronic States[**]期刊论文

作者:Nurit Ashkenasy,W. Seth Horne,M. Reza Ghadiri等   ISSN:1613-6810;1613-6829;  publication-date:2007-1-8  Volume:2  Issue:1  Page:99-102  

One-pot synthesis of CdTe nanocrystals and shape control of luminescent CdTe-cystine nanocomposites期刊论文

作者:Bao HF,Wang EK,Dong SJ等   ISSN:1613-6810  publication-date:2006  Volume:2  Issue:4  Page:476-480  

Site-specific ligation of DNA-modified gold nanoparticles activated by the restriction enzyme StyI期刊论文

作者:Kanaras AG,Wang ZX,Hussain I,Brust M,Cosstick R,Bates AD等   ISSN:1613-6810  publication-date:2007  Volume:3  Issue:1  Page:67-70  

Nanoscale phase-aggregation-induced performance improvement of polymer solar cells期刊论文

作者:Yang XN,Lu GH,Li LG,Zhou EL等   ISSN:1613-6810  publication-date:2007  Volume:3  Issue:4  Page:611-615  

Creating a uniform distribution of fullerene C-60 nanorods in a polymer matrix and its photovoltaic applications期刊论文

作者:Lu GH,Li LG,Yang XN等   ISSN:1613-6810  publication-date:2008  Volume:4  Issue:5  Page:601-606  

Self-assembly of single-stranded RNA on carbon nanotube: Polyadenylic acid to form a duplex structure期刊论文

作者:Zhao C,Peng YH,Song YJ,Ren JS,Qu XG等   ISSN:1613-6810  publication-date:2008  Volume:4  Issue:5  Page:656-661  

Label-Free Colorimetric Detection of Small Molecules Utilizing DNA Oligonucleotides and Silver Nanoparticles期刊论文

作者:Xu XW,Wang J,Yang F,Jiao K,Yang XR等   ISSN:1613-6810  publication-date:2009  Volume:5  Issue:23  Page:2669-2672  

Polyaniline/Pt Hybrid Nanofibers: High-Efficiency Nanoelectrocatalysts for Electrochemical Devices期刊论文

作者:Guo SJ,Dong SJ,Wang EK等   ISSN:1613-6810  publication-date:2009  Volume:5  Issue:16  Page:1869-1876  

A renewable SERS substrate prepared by cyclic depositing and stripping of silver shells on gold nanoparticle microtubes期刊论文

作者:Wang T,Hu XG,Dong SJ等   ISSN:1613-6810  publication-date:2008  Volume:4  Issue:6  Page:781-786  

Shape- and size-controlled synthesis and dependent magnetic properties of nearly monodisperse Mn3O4 nanocrystals期刊论文

作者:Zhao NN,Nie W,Liu XB,Tian SZ,Zhang Y,Ji XL等   ISSN:1613-6810  publication-date:2008  Volume:4  Issue:1  Page:77-81  





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